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John A Kirby Selected Research

Therapeutics

1/2023Anti-Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct-Ligated Mice.
11/2021Regulation and Role of αE Integrin and Gut Homing Integrins in Migration and Retention of Intestinal Lymphocytes during Inflammatory Bowel Disease.
9/2021Targeting Leukocyte Trafficking in Inflammatory Bowel Disease.
7/2014Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial.
3/2012Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-β1-dependent mechanism.
9/2008Celecoxib has potent antitumour effects as a single agent and in combination with BCG immunotherapy in a model of urothelial cell carcinoma.
12/2002Oral tolerisation to pyruvate dehydrogenase complex as a potential therapy for primary biliary cirrhosis.

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John A Kirby Research Topics

Disease

20Inflammation (Inflammations)
01/2023 - 09/2003
8Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
05/2019 - 02/2002
7Brain Death (Brain Dead)
10/2010 - 06/2003
6Breast Neoplasms (Breast Cancer)
07/2021 - 03/2007
5Lung Injury
10/2010 - 06/2003
4Neoplasms (Cancer)
09/2021 - 03/2007
4Neoplasm Metastasis (Metastasis)
07/2021 - 11/2002
4Ulcerative Colitis
12/2017 - 07/2014
4Hypotension (Low Blood Pressure)
06/2009 - 04/2005
4Liver Diseases (Liver Disease)
02/2008 - 02/2002
3Reperfusion Injury
07/2023 - 10/2010
3Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
11/2021 - 02/2016
3Necrosis
09/2016 - 01/2007
2Infections
01/2023 - 09/2021
2Osteolysis
11/2016 - 09/2016
2Fibrosis (Cirrhosis)
07/2014 - 01/2003
2Urinary Bladder Neoplasms (Bladder Cancer)
09/2008 - 11/2002
2Sepsis (Septicemia)
01/2006 - 04/2004
1Neurobehavioral Manifestations
01/2023
1Cholestasis
01/2023
1Lymphatic Metastasis
07/2021
1Rheumatoid Arthritis
03/2012
1Lung Diseases (Lung Disease)
03/2012
1Herpes Zoster
05/2010
1Non-Muscle Invasive Bladder Neoplasms
09/2008
1Carcinoma (Carcinomatosis)
09/2008

Drug/Important Bio-Agent (IBA)

16ChemokinesIBA
01/2023 - 01/2004
7Chemokine ReceptorsIBA
07/2021 - 04/2004
5IntegrinsIBA
11/2021 - 04/2004
5Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA
12/2008 - 02/2002
4CytokinesIBA
07/2014 - 01/2006
4Norepinephrine (Noradrenaline)FDA LinkGeneric
06/2009 - 04/2005
3GlycosaminoglycansIBA
01/2019 - 07/2005
3etrolizumabIBA
11/2018 - 07/2014
3Transforming Growth Factor beta (TGF-beta)IBA
05/2010 - 01/2003
3EnzymesIBA
12/2008 - 02/2002
2Interleukin-8 (Interleukin 8)IBA
01/2023 - 04/2004
2CobaltIBA
11/2016 - 09/2016
2MetalsIBA
11/2016 - 09/2016
2Proteins (Proteins, Gene)FDA Link
09/2014 - 12/2012
2Heparitin Sulfate (Heparan Sulfate)IBA
07/2014 - 11/2009
2Toll-Like Receptors (Toll-Like Receptor)IBA
10/2010 - 01/2007
2InterferonsIBA
10/2010 - 01/2007
2Messenger RNA (mRNA)IBA
10/2010 - 02/2008
2Nitric Oxide (Nitrogen Monoxide)FDA Link
10/2010 - 06/2003
2Cadherins (E-Cadherin)IBA
05/2010 - 11/2002
2Chemokine CCL7IBA
11/2009 - 07/2005
2Arginine Vasopressin (Argipressin)IBA
06/2009 - 02/2008
2LigandsIBA
06/2009 - 07/2005
2Vasopressins (Vasopressin)IBA
06/2009 - 05/2008
1Inflammation MediatorsIBA
07/2023
1Chemokine CCL21IBA
07/2021
1Bile Acids and Salts (Bile Acids)IBA
05/2019
1Interleukin-6 (Interleukin 6)IBA
05/2019
1Peptides (Polypeptides)IBA
01/2019
1Chemokine CXCL12IBA
11/2018
1alpha E integrinsIBA
11/2018
1Biomarkers (Surrogate Marker)IBA
11/2018
1integrin beta7IBA
12/2017
1AlloysIBA
09/2016
1Granzymes (Granzyme)IBA
02/2016
1Monoclonal AntibodiesIBA
02/2016
1NitrogenIBA
10/2014
1Reactive Nitrogen SpeciesIBA
10/2014
1Peroxynitrous Acid (Peroxynitrite)IBA
10/2014
1Oxygen (Dioxygen)IBA
10/2014
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
07/2014
1AntibodiesIBA
08/2013
1Transcription Factors (Transcription Factor)IBA
12/2012
1AntioxidantsIBA
03/2012
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
04/2011
1Aprotinin (Trasylol)FDA Link
10/2010
1sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
09/2010
1S100 Calcium-Binding Protein A4IBA
05/2010
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
05/2010
1VimentinIBA
05/2010
1Fibronectins (Fibronectin)IBA
05/2010
1Interferon-gamma (Interferon, gamma)IBA
12/2009
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
12/2009
1Heme Oxygenase-1IBA
06/2009
1Interleukin-1beta (Interleukin 1 beta)IBA
06/2009
1AntigensIBA
12/2008
1EpitopesIBA
12/2008
1Thioctic Acid (Lipoic Acid)IBA
12/2008
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
09/2008
1Dinoprostone (PGE2)FDA Link
09/2008
1Celecoxib (Celebrex)FDA Link
09/2008
1GlycoconjugatesIBA
08/2008
1OligosaccharidesIBA
08/2008
1Nuclear Proteins (Protein, Nuclear)IBA
05/2008
1Poly Adenosine Diphosphate RiboseIBA
05/2008

Therapy/Procedure

7Therapeutics
01/2023 - 12/2002
5Transplantation
10/2014 - 06/2003
3Resuscitation
06/2009 - 02/2008
2Ligation
01/2023 - 03/2007
1Organ Transplantation
10/2014
1Drug Therapy (Chemotherapy)
04/2011
1Catheters
10/2010
1Lung Transplantation
10/2010
1Immunotherapy
09/2008